Ammonia → HCID 73776649, compound

Participants

Reaction Steps

(S)-2-(1-((5-(2-Fluorophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (35 mg, 0.06 mmol) was treated with trifluoroacetic acid (600 μl, 7.79 mmol) and a solution of ammonia (7N in methanol, 600 μl, 4.2 mmol) according to the method described in Example 27 to give 15 mg (54% yield) of the title compound as a white solid. Purity 89%.

Provenance & Evidence