Ammonia → (S)-N-(2-Methoxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridin-3-yl)methanesulfonamide

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Reaction Steps

(S)—N-(2-Methoxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridin-3-yl)methanesulfonamide (82.5 mg, 0.12 mmol) was treated with trifluoroacetic acid (1.4 ml, 18.17 mmol) and a solution of ammonia (7N in methanol, 1.4 ml, 9.8 mmol) according to the method described in Example 27 to give 22 mg (32% yield) of the title compound as a white solid. Purity 95%.

Provenance & Evidence