Ammonia → HCID 73776363, compound

Participants

Reaction Steps

2-((1S)-1-((5-(2-Fluoro-6-methoxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (50 mg, 0.07 mmol) was treated with boron tribromide (1M in dichloromethane, 680 μl, 0.68 mmol) and a solution of ammonia (7N in methanol, 1 mL, 7 mmol) according to the method described in Example 41 to give 12 mg (36% yield) of the title compound as a white solid. Purity 97%.

Provenance & Evidence