Ammonia → HCID 73776211, compound

Participants

Reaction Steps

(S)-2-(1-((5-(5-Fluoro-2-methoxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (55 mg, 0.09 mmol) was treated with boron tribromide (1 M in dichloromethane, 1 mL, 1 mmol) and a solution of ammonia (7N in methanol, 1 mL, 7 mmol) according to the method described in Example 27 to give 20 mg (47% yield) of the title. Purity 94%.

Provenance & Evidence