Ammonia → HCID 73775415, compound

Participants

Reaction Steps

(S)-2-(1-((5-(1H-Indol-7-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (91 mg, 0.14 mmol) was treated with trifluoroacetic acid (1.82 mL, 23.62 mmol) and a solution of ammonia (7N in methanol, 1.82 mL, 12.74 mmol) according to the method described in Example 27 to give 8 mg (11% yield) of the title compound. Purity 98%.

Provenance & Evidence