Boron tribromide → (S)-2-(1-((6-Amino-5-(3-hydroxybenzyl)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Participants

Reaction Steps

(S)-2-(1-((6-Amino-5-(3-methoxybenzyl)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (70 mg, 0.15 mmol) was treated with boron tribromide (1M in dichloromethane, 436 μl, 0.44 mmol) with dichloromethane as a solvent according to the method described in Example 23. The residue was purified by reverse phase using SP1® Purification System to give 37 mg (54% yield) as a solid. Purity 98%.

Provenance & Evidence