Ammonia → N-[3-[4-[[(1S)-1-(5-methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]methanesulfonamide

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Reaction Steps

(S)—N-(3-(4-((1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)methanesulfonamide (79 mg, 0.12 mmol) was treated with trifluoroacetic acid (1.58 mL, 20.51 mmol) and a solution of ammonia (7N in methanol, 1.58 mL, 11.06 mmol) according to the method described in Example 27 to give 23 mg (36% yield) of the title compound. Purity 97%.

Provenance & Evidence