反应详情

(S)-2-(1-((6-Amino-5-((3-fluoro-4-methoxyphenyl)thio)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (233 mg, 0.45 mmol) was treated with boron tribromide (1M in dichloromethane, 1.35 ml, 1.35 mmol) with dichloromethane as a solvent according to the method described in Example 23. The residue was purified by reverse phase using SP1® Purification System to give 40 mg (18% yield) as a solid. Purity 99%.

1. customThe residue was purified by reverse phase
2. custom® Purification System
3. customto give 40 mg (18% yield) as a solid