Ammonia → HCID 73775412, compound

Participants

Reaction Steps

(S)-2-(1-((5-(3-Fluoro-5-methoxybenzyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (3 mg, 0.01 mmol) was treated with boron tribromide (1M in dichloromethane, 148 μL, 0.15 mmol) in dichloromethane (280 μL) and then with a solution of ammonia (7N in methanol, 280 μl, 1.96 mmol) according to the method described in Example 41. The residue was purified using SP1® Purification System (0% to 100% dichloromethane-ethyl acetate) to obtain 3 mg (38% yield) of the title compound.

Provenance & Evidence