Ammonia → HCID 73775413, compound

Participants

Reaction Steps

(S)—N-(3-Methyl-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)methanesulfonamide (110 mg, 0.16 mmol) was treated with trifluoroacetic acid (2 ml, 26 mmol) and a solution of ammonia (7N in methanol, 2 ml, 90 mmol) according to the method described in Example 27 to give 25 mg (28% yield) of the title compound. Purity 98%.

Provenance & Evidence