Ammonia → HCID 73775414, compound

Participants

Reaction Steps

(S)-5-Methyl-3-phenyl-2-(1-((5-(phenylethynyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (9 mg, 0.01 mmol) was treated with trifluoroacetic acid (180 μl, 2.34 mmol) and a solution of ammonia (7N in methanol, 180 μl, 1.26 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 100% n-hexane-ethyl acetate) to obtain 7 mg (98% yield) of the title compound.

Provenance & Evidence