Ammonia → HCID 73775933, compound

Participants

Reaction Steps

(S)-5-Methyl-2-(1-((5-(3-(morpholinosulfonyl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (90 mg, 0.12 mmol) was treated with trifluoroacetic acid (2 ml, 25 mmol) and a solution of ammonia (7N in methanol, 2 ml, 91 mmol) according to the method described in Example 27. The residue was purified by reverse phase using SP1® Purification System to obtain 19 mg (25% yield) of the title compound. Purity 98%.

Provenance & Evidence