Ammonia → HCID 73776070, compound

Participants

Reaction Steps

(S)-2-(1-((5-(4-Hydroxy-3-methoxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (63 mg, 0.10 mmol) was treated with trifluoroacetic acid (1.26 ml, 16.36 mmol) and a solution of ammonia (7N in methanol, 1.26 ml, 8.82 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 6% n-hexane-ethyl acetate) to obtain 23 mg (46% yield) of the title compound.

Provenance & Evidence