Ammonia → HCID 73776071, compound

Participants

Reaction Steps

(S)-2-(1-((5-((2-Methoxyphenyl)thio)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (57 mg, 0.09 mmol) was treated with boron tribromide (1M in dichloromethane, 872 μL, 0.87 mmol) in dichloromethane (1.14 mL) and then with a solution of ammonia (7N in methanol, 1.14 ml, 7.98 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 100% dichloromethane ethyl acetate) to obtain 23 mg (47% yield, 90% purity) of the title compound.

Provenance & Evidence