Ammonia → HCID 90102672, compound

Participants

Reaction Steps

(S)-2-(1-((5-((4-Methoxyphenyl)thio)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (65 mg, 0.10 mmol) was treated with boron tribromide (1M in dichloromethane, 894 μL, 0.99 mmol) in dichloromethane (1.3 mL) and then with a solution of ammonia (7N in methanol, 1.3 ml, 9.10 mmol) according to the method described in Example 41. The residue was purified using SP1® Purification System (0% to 100% dichloromethane ethyl acetate) to obtain 24 mg (48% yield) of the title compound.

Provenance & Evidence