Boron tribromide → (S)-4-Amino-N-(5-carbamoyl-2-hydroxyphenyl)-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidine-5-carboxamide

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Reaction Steps

(S)-4-Amino-N-(5-carbamoyl-2-methoxyphenyl)-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidine-5-carboxamide (400 mg, 49% purity, 0.35 mmol) was treated with boron tribromide (1M in dichloromethane, 1.1 ml, 1 mmol) in dichloromethane (8 ml) according to the method described in Example 23. The residue was purified by reverse phase using SP1® Purification System to give 10 mg (5% yield) as a solid. Purity 90%.

Provenance & Evidence