Ammonia → HCID 90102635, compound

Participants

Reaction Steps

(S)-2-(1-((5-(3-Amino-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (36 mg, 0.06 mmol) was treated with trifluoroacetic acid (720 μl, 9.35 mmol) and a solution of ammonia (7N in methanol, 720 μl, 6.04 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 20% dichloromethane-methanol) to obtain 22 mg (75% yield) of the title compound.

Provenance & Evidence