Boron tribromide → HCID 90102538, compound

Participants

Reaction Steps

(S)—N-(3-Methoxyphenyl)-4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidine-5-carboxamide (80 mg, 72% purity, 0.12 mmol) was treated with boron tribromide (1M in dichloromethane, 0.6 ml, 0.6 mmol) in dichloromethane (2 ml) according to the method described in Example 23. The residue was purified using SP1® Purification System (0% to 10%, DCM-MeOH) to give 8 mg (14% yield) as a solid. Purity 95%.

Provenance & Evidence