Ammonia → (S)-N-(3-Hydroxy-5-(3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrazol-1-yl)phenyl)methanesulfonamide

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Reaction Steps

(S)—N-(3-Methoxy-5-(3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrazol-1-yl)phenyl)methanesulfonamide (15 mg, 0.01 mmol) was treated with boron tribromide (1M in dichloromethane, 1 ml, 1 mmol) in dichloromethane (1 ml) and then with a solution of ammonia (7N in methanol, 10 ml, 70 mmol) according to the method described in Example 41 to give 4.2 mg (44% yield) of the title compound. Purity 92%.

Provenance & Evidence