Ammonia → HCID 90102857, compound

Participants

Reaction Steps

(S)-2-(1-((5-(3-Chloro-2-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (58 mg, 0.07 mmol) was treated with trifluoroacetic acid (1.20 ml, 15.58 mmol) and a solution of ammonia (7N in methanol, 1.20 ml, 8.40 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 5% dichloromethane-2-propanol) to obtain 8 mg (21% yield) of the title compound.

Provenance & Evidence