Ammonia → HCID 90102596, compound

Participants

Reaction Steps

(S)—N-(5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridin-3-yl)methanesulfonamide (53 mg, 0.06 mmol) was treated with trifluoroacetic acid (1.05 ml, 13.63 mmol) and a solution of ammonia (7N in methanol, 1.05 ml, 7.35 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 10% dichloromethane-2-propanol) to obtain 22 mg (68% yield) of the title compound.

Provenance & Evidence