Ammonia → (S)-4-Hydroxy-N-(3-hydroxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)benzenesulfonamide

Participants

Reaction Steps

(S)—N-(3-Hydroxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)-4-methoxybenzenesulfonamide (40 mg, 0.04 mmol) was treated with boron tribromide (1M in dichloromethane, 388 μl, 0.39 mmol) in dichloromethane (800 μl) and then with a solution of ammonia (7N in methanol, 800 μl, 5.60 mmol) according to the method described in Example 41. The residue was purified using SP1® Purification System (0% to 10% dichloromethane-2-propanol) to obtain 3 mg (11% yield, 88% purity) of the title compound.

Provenance & Evidence