Potassium Carbonate → HCID 118434019, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-2-(1-((6-amino-5-(5-hydroxypyridin-3-yl)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (49 mg, 0.11 mmol), 1,1,1-trifluoro-2-iodoethane (13 μl, 0.13 mmol) and potassium carbonate (30 mg, 0.22 mmol) in N,N-dimethylformamide (3 ml) was stirred at 120° C. under microwave irradiation for 2 h. Further 1,1,1-trifluoro-2-iodoethane (13 μl, 0.13 mmol) and potassium carbonate (15 mg, 0.11 mmol) were added and the reaction mixture was stirred at 120° C. under microwave irradiation for 2 h. The residue was purified by reverse phase using SP1® Purification System to give 32 mg (55% yield) as a solid. Purity 100%.

Provenance & Evidence