Ammonia → N-[4-[4-[[(1S)-1-(5-methyl-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-1H-indol-6-yl]methanesulfonamide

Participants

Reaction Steps

(S)—N-(4-(4-((1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-6-yl)methanesulfonamide (87 mg, 0.12 mmol) was treated with trifluoroacetic acid (2.5 ml, 32 mmol) and a solution of ammonia (7N in methanol, 1.25 ml, 17 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 50% dichloromethane-2-propanol) to obtain 60 mg (80% yield) of the title compound. Purity 95%.

Provenance & Evidence