Ammonia → HCID 73508003, compound

Participants

Reaction Steps

(S)-2-(1-((5-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (51 mg, 0.08 mmol) was treated with trifluoroacetic acid (2 ml, 25 mmol) and a solution of ammonia (7N in methanol, 2 ml, 14 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 50% dichloromethane-2-propanol) to obtain 18 mg (44% yield) of the title compound. Purity 100%.

Provenance & Evidence