Ammonia → HCID 90102230, compound

Participants

Reaction Steps

(S)-2-(1-((5-(1-(3-((tert-Butyldimethylsilyl)oxy)propyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (124 mg, 0.14 mmol) was treated with trifluoroacetic acid (1 ml, 13 mmol) and a solution of ammonia (7N in methanol, 2 ml, 14 mmol) according to the method described in Example 27 to give 48 mg (68% yield) of the title compound. Purity 99%.

Provenance & Evidence