Ammonia → HCID 118433787, compound

Participants

Reaction Steps

(S)-3-Methoxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile (34 mg, 0.05 mmol) was treated with boron tribromide (1M in dichloromethane, 526 μL, 0.53 mmol) in dichloromethane (680 μL) and then with a solution of ammonia (7N in methanol, 680 μl, 4.76 mmol) according to the method described in Example 41. The residue was purified using SP1® Purification System (0% to 15% dichloromethane-2-propanol) to obtain 19 mg (69% yield) of the title compound.

Provenance & Evidence