Ammonia → HCID 90102219, compound

Participants

Reaction Steps

(S)-2-(Dimethylamino)-N-(3-hydroxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)ethanesulfonamide (15 mg, 0.02 mmol, 77% purity) was treated with trifluoroacetic acid (300 μl, 3.89 mmol) and a solution of ammonia (7N in methanol, 300 μl, 2.10 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 40% dichloromethane methanol) to obtain 5 mg (52% yield) of the title compound.

Provenance & Evidence