Ammonia → HCID 136623656, compound

Participants

Reaction Steps

(S)-5-Methyl-2-(1-((5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (38 mg, 0.04 mmol, 66% purity) was treated with trifluoroacetic acid (760 μl, 9.86 mmol) and a solution of ammonia (7N in methanol, 760 μl, 5.32 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (reverse phase, 0% to 100% water-methanol/acetonitrile 1:1) to obtain 14 mg (69% yield) of the title compound.

Provenance & Evidence