Ammonia → HCID 136623664, compound

Participants

Reaction Steps

(S)-2-(1-((5-(1-(3-Hydroxy-2,2-dimethylpropyl)-1H-pyrazol-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (4 mg, 0.01 mmol) was treated with trifluoroacetic acid (1 mL, 13 mmol) and a solution of ammonia (7N in methanol, 5 mL, 35 mmol) according to the method described in Example 27 to give 3.2 mg (100% yield) of the title compound. Purity 85%.

Provenance & Evidence