Hydrochloric Acid → HCID 118433905, compound

Participants

Reaction Steps

(S)-tert-Butyl 4-(4-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)phenyl)piperazine-1-carboxylate (75 mg, 0.12 mmol) was dissolved in 2 ml dioxane. A solution of hydrochloric acid (4M in dioxane, 30 μL, 0.12 mol) was added and the reaction was stirred at room temperature for 2 h. The solvent was removed and the residue was purified by preparative HPLC-MS to give 12 mg (19% yield) of the title compound as a solid. Purity 100%.

Provenance & Evidence