Ammonia → HCID 90102949, compound

Participants

Reaction Steps

(S)—N-(4-Hydroxy-3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)methanesulfonamide (102 mg, 0.15 mmol) was treated with trifluoroacetic acid (2.7 ml, 35.05 mmol) and a solution of ammonia (7N in methanol, 2.7 ml, 19 mmol) according to the method described in Example 27 to give 26 mg (29% yield) of the title compound. Purity 93%.

Provenance & Evidence