Ammonia → HCID 90103172, compound

Participants

Reaction Steps

(S)-1-(3-Hydroxy-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)urea (18 mg, 0.03 mmol) was treated with trifluoroacetic acid (360 μl, 4.07 mmol) and a solution of ammonia (7N in methanol, 360 μl, 2.52 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 15% dichloromethane-2-propanol) to obtain 13 mg (90% yield) of the title compound.

Provenance & Evidence