Ammonia → (S)-3-(Methylsulfonamido)-5-(4-((1-(4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl methanesulfonate

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Reaction Steps

(S)-3-(Methylsulfonamido)-5-(4-((1-(4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl methanesulfonate (82 mg, 0.07 mmol) was treated with trifluoroacetic acid (3 ml, 39 mmol) and a solution of ammonia (7N in methanol, 2.5 ml, 18 mmol) according to the method described in Example 27 to give 23 mg (52% yield) of the title compound. Purity 99%.

Provenance & Evidence