Ammonia → HCID 90102599, compound

Participants

Reaction Steps

(S)-3-Methoxy-N-methyl-4-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzenesulfonamide (45 mg, 0.06 mmol) was treated with boron tribromide (1M in dichloromethane, 2.0 mL, 2.00 mmol) in dichloromethane (1 mL) and then with a solution of ammonia (7N in methanol, 5.0 mL, 35.0 mmol) according to the method described in Example 41. The residue was purified using SP1® Purification System (reverse phase, 0% to 100% water methanol/acetonitrile 1:1) to obtain 8 mg (22% yield) of the title compound.

Provenance & Evidence