Ammonia → HCID 90103103, compound

Participants

Reaction Steps

(S)-3-Hydroxy-N,N-dimethyl-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzamide (44 mg, 0.06 mmol, 89% purity) was treated with trifluoroacetic acid (880 μl, 11.42 mmol) and a solution of ammonia (7N in methanol, 880 μl, 6.16 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 15% dichloromethane-2-propanol) to obtain 27 mg (85% yield) of the title compound.

Provenance & Evidence