Ammonia → HCID 90102641, compound

Participants

Reaction Steps

(S)—N-(3-(4-((1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-5-morpholinophenyl)methanesulfonamide (27 mg, 0.02 mmol) was treated with trifluoroacetic acid (0.45 ml, 5.84 mmol) and a solution of ammonia (7N in methanol, 0.45 ml, 3.15 mmol) according to the method described in Example 27 to give 11 mg (71% yield) of the title compound. Purity 100%.

Provenance & Evidence