Ammonia → HCID 90103140, compound

Participants

Reaction Steps

(S)-5-Methyl-2-(1-((5-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (90 mg, 0.13 mmol) was treated with trifluoroacetic acid (2 ml, 25 mmol) and a solution of ammonia (7N in methanol, 2 ml, 100 mmol) according to the method described in Example 27 to give 15 mg (20% yield) of the title compound. Purity 95%.

Provenance & Evidence