Water → HCID 118433858, compound

Participants

Reaction Conditions

Reaction Steps

(S)-2-(1-((6-amino-5-(1-((4-methoxyphenyl)sulfonyl)-1H-indazol-6-yl)pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (77 mg, 0.12 mmol) was treated with pyridine hydrochloride (2.7 g, 115 mmol) and heated at 180° C. for 2 h. Water and ethyl acetate were added and the organic phase was washed with water and brine and then concentrated. The residue was purified using SP1® Purification System (0% to 75%, hexane-ethyl acetate) to obtain 12 mg (22% yield) of the title compound as a white solid. Purity 98%.

Provenance & Evidence