Ammonia → HCID 90102696, compound

Participants

Reaction Steps

(S)-2-(1-((5-(3-Hydroxy-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (50 mg, 0.07 mmol) was treated with trifluoroacetic acid (2 ml, 25 mmol) and a solution of ammonia (7N in methanol, 3 ml, 135 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (DCM to DCM-Isopropyl alcohol 15%) to give 10 mg (67% yield) of the title compound. Purity 98%.

Provenance & Evidence