Ammonia → HCID 90102223, compound

Participants

Reaction Steps

(S)-2-(1-((5-(3-(5-Amino-1,3,4-oxadiazol-2-yl)-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (40 mg, 0.06 mmol) was treated with trifluoroacetic acid (1 ml, 13 mmol) and a solution of ammonia (7N in methanol, 1 ml, 59 mmol) according to the method described in Example 27. The residue was purified by reverse phase chromatography using SP1® Purification System to give 5 mg (15% yield) of the title compound. Purity 98%.

Provenance & Evidence