Ammonia → HCID 118433784, compound

Participants

Reaction Steps

(S)—N-(6-(4-((1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-4-yl)methanesulfonamide (37 mg, 0.05 mmol) was treated with trifluoroacetic acid (1 ml, 13 mmol) and a solution of ammonia (7N in methanol, 1 ml, 7 mmol) according to the method described in Example 27 to give 17 mg (53% yield) of the title compound. Purity 95%. LRMS (m/z): 594 (M+1)+.

Provenance & Evidence