反应详情

(S)—N-(3-(4-Amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)phenyl)-2,4-dimethoxybenzenesulfonamide (108 mg, 0.17 mmol) was treated with boron tribromide (1M in dichloromethane, 0.90 ml, 0.9 mmol) with dichloromethane (20 ml) as a solvent at 100° C. for 2 h under microwave conditions. After evaporation of the solvent and usual workup with ethyl acetate and water, the residue was purified by reverse phase chromatography using SP1® Purification System to give 48 mg (55% yield) as a solid. Purity 99%.

1. customAfter evaporation of the solvent and usual workup with ethyl acetate and water
2. customthe residue was purified by reverse phase chromatography
3. customSP1® Purification System
4. customto give 48 mg (55% yield) as a solid