Boron tribromide → (S)-N-(5-(4-Amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-2-(ethylamino)pyridin-3-yl)-4-hydroxybenzenesulfonamide

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Reaction Steps

(S)—N-(5-(4-Amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-2-(ethylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide (18 mg, 0.03 mmol) was treated with boron tribromide (1M in dichloromethane, 0.1 ml, 0.10 mmol) with dichloromethane (1 ml) as a solvent according to the method described in Example 23. The residue was purified by reverse phase using SP1® Purification System to give 6 mg (32% yield) as a solid. Purity 93%.

Provenance & Evidence