Ammonia → HCID 118433862, compound

Participants

Reaction Steps

(S)—N,N-Dimethyl-3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-5-(methylsulfonamido)benzamide (215 mg, 0.28 mmol) was treated with trifluoroacetic acid (3.0 ml, 39 mmol) and a solution of ammonia (7N in methanol, 3.0 ml, 21 mmol) according to the method described in Example 27 to give 144 mg (81% yield) of the title compound. Purity 99%.

Provenance & Evidence