Ammonia → HCID 118433720, compound

Participants

Reaction Steps

(S)-2-(1-((5-(2-(4-(Dimethylamino)piperidin-1-yl)pyridin-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (12 mg, 0.02 mmol) was treated with trifluoroacetic acid (1 ml, 13 mmol) and a solution of ammonia (7N in methanol, 1 ml, 60 mmol) according to the method described in Example 27 to give 5 mg (50% yield) of the title compound as a solid. Purity 98%.

Provenance & Evidence