Ammonia → HCID 118433826, compound

Participants

Reaction Steps

(S)-1-(4-(4-((1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-6-yl)urea (40 mg, 0.06 mmol) was treated with trifluoroacetic acid (800 μl, 10.38 mmol) and a solution of ammonia (7N in methanol, 800 μl, 5.60 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 20% dichloromethane methanol) to obtain 26 mg (80% yield) of the title compound.

Provenance & Evidence