反应详情

(S)—N-(3-Fluoro-5-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)-2-methoxyethanesulfonamide (29 mg, 0.03 mmol, 78% purity) was treated with boron tribromide (1M in dichloromethane, 303 μl, 0.30 mmol) with dichloromethane (580 μl) as a solvent according to the method described in Example 23. and then with a solution of ammonia (7N in methanol, 600 μl, 4.20 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 15% dichloromethane-2-propanol) to obtain 15 mg (82% yield) of the title compound.

1. customThe residue was purified
2. customSP1® Purification System (0% to 15% dichloromethane-2-propanol)