HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-(4-Fluorophenyl)-5-(morpholin-4-yl)pentane-1,5-dione | HCID 58070809 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one | HCID 23636213 | — |
Reaction Steps
As per the present invention, the ketoreductase enzyme is dissolved in buffer and to this a solution of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione in an alcohol solvent such as methanol is added at a temperature of 20-40° C. for 15-40 hours and monitored by HPLC. To this immiscible organic solvent such as ethyl acetate is added and (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one is isolated from organic phase.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388440B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-6e317a9f930840f9b2760d5d5097404a |
| Source note | uspto-grants-2016_07 |