反应详情

10 gms of 3-[5-Benzyloxy-2-[(4-benzyloxy-phenyl)-(4-fluoro-phenylamino)-methyl]-5-(4-fluoro-phenyl)-pentanoyl]-4-phenyl-oxazolidin-2-one was taken in dichloromethane, to this 3.6 gms of sodium methoxide was added followed by 3.2 ml of dimethylcarbonate, and 500 ml of dichloromethane. Reaction mass was stirred for about 5-7 hours. To the reaction mass 0.1 ml of hydrochloric acid was added. Separated the layers and extract the aqueous layer with 25 ml of methylene dichloride. The organic layer was washed with water and dried over sodium sulphate. Distilled the solvent completely under reduced pressure at 50-55° C. and 85 ml of methanol was added. Stirred the reaction mass for about 1-2 hours, filtered and washed with methanol and dried at 50-55° C. to get 5 gms of 5-Benzyloxy-2-[(4-benzyloxy-phenyl)-(4-fluoro-phenylamino)-methyl]-5-(4-fluoro-phenyl)-pentanoic acid methyl ester.

1. additionwas added
2. customReaction mass
3. customSeparated the layers
4. extractionextract the aqueous layer with 25 ml of methylene dichloride
5. washThe organic layer was washed with water
6. dry with materialdried over sodium sulphate
7. distillationDistilled the solvent completely under reduced pressure at 50-55° C.
8. addition85 ml of methanol was added
9. stirringStirred the reaction mass for about 1-2 hours
10. filtrationfiltered
11. washwashed with methanol
12. customdried at 50-55° C.